Do Ozempic and other GLP-1 medications affect dental sedation?

Why we ask about weight-loss and diabetes injections before IV sedation, and what to do.

Dr Bill Kalis — Saturday 14 November 2026

Yes. Medications such as Ozempic, Wegovy and Mounjaro slow the emptying of your stomach, so food can still be there after a normal fast. That matters for sedation, so we need to know if you take one. You can usually still have IV sedation, with fasting instructions made for you.

I am Dr Bill Kalis, principal dentist at Padstow Dental in Padstow, Sydney. Our sedationists ask every patient about these medications.

What are GLP-1 medications?

They are medications used for type 2 diabetes and weight management. Most are weekly injections, and some are tablets. Common names include semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro), liraglutide (Saxenda) and dulaglutide (Trulicity).

Why do they matter for sedation?

Under sedation, the reflexes that protect your airway are reduced. If the stomach is not empty, there is a risk that its contents could come up and enter the lungs. This is why everyone fasts before sedation. GLP-1 medications slow the stomach, so the usual fasting time may not be enough.

What will I be asked to do?

The sedationist gives you instructions based on your medication, your dose and your health. These may include a longer fast or a period of clear fluids only beforehand. Follow the written instructions you are given, because they are specific to you.

Should I stop my medication before sedation?

Do not stop or skip your medication on your own. Whether to pause it is a decision for the sedationist and your prescribing doctor, particularly if you take it for diabetes.

What should I tell the practice?

• The name of your medication and the dose

• The day you take it, and when you started

• Whether your dose has changed recently

• Any nausea, vomiting, reflux or bloating

• Every other medication and supplement you take

Tell us when you book, not on the day, so there is time to plan.

Does this apply to treatment without sedation?

No. Treatment under local anaesthetic alone does not need fasting, and you take your medication as usual.

Common questions about GLP-1 medications and sedation

Can I still have my wisdom teeth out under IV sedation?

In most cases, yes. We plan your fasting around your medication.

What if I forget to mention it?

Tell us as soon as you remember. Your appointment may need to be changed to sedation on another day.

Does it matter that I take it for weight loss and not diabetes?

No. The effect on the stomach is the same.

I take the tablet form. Does that count?

Yes. Tell us about tablets as well as injections.

Planning treatment under sedation?

Read about IV sedation at Padstow Dental or call 02 9773 4775. This article is general information and does not replace the instructions your sedationist gives you.

Any surgical or invasive procedure carries risks. Before proceeding, you should seek a second opinion from an appropriately qualified health practitioner.

Written by Dr Bill Kalis, Principal Dentist at Padstow Dental. BDS (Hons), University of Sydney, 1994. Graduate Certificate in Clinical Dentistry, University of Adelaide, 2007. Past State and Federal President of the Australian Society of Implant Dentistry. Dr Kalis is a general dentist with a focus on implant, surgical and IV sedation dentistry.